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Diabetes Pathogenesis
COX2 (PTGS2) inhibitors augment hexose transport rate in insulin- and AMPK alpha-independent way
April 10th, 2006
Cyclooxygenase-2 (PTGS2) inhibitors augment the rate of hexose transport in L6 myotubes in an insulin- and AMPK alpha-independent manner. " Some cyclooxygenase-2 (COX2, also known as prostaglandin-endoperoxide synthase 2 [PTGS2]) inhibitors have been shown to increase insulin sensitivity in man or induce hypoglycemic episodes when over-consumed or taken in combination with oral hypoglycemic drugs. These side-effects and their impact on patients are not always recognized in routine clinical practice," investigators in Israel report. E. Alpert and colleagues at the Hebrew University of Jerusalem investigated "whether these side-effects of COX2 (PTGS2)...
Source: Diabetes Week (2006-04-10)
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