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Diabetes Pathogenesis
Ca2+ overload and high Ca2+ transport are linked to salivary cell impairment in diabetes
April 10th, 2006
Diabetes causes impairment of salivary cells function that associates with Ca2+ overload and increased Ca2+-mobilizing ability of muscarinic receptros. According to recent research from the United States, "Xerostomia and pathological thirst are troublesome complications of diabetes mellitus associated with impaired functioning of salivary glands; however, their cellular mechanisms are not yet determined. Isolated acinar cells were loaded with Ca2+ indicators fura-2/AM for measuring cytosolic Ca2+ concentration ([Ca2+]i ) or mag-fura-2/AM-inside the endoplasmic reticulum (ER)." "We...
Source: Diabetes Week (2006-04-10)
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