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Diabetes Pathogenesis
Decrease in PI-3K/AKT1 survival signaling mediates DN-HNF-1alpha-induced apoptosis
April 10th, 2006
Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function. "Inactivating mutations in Tcf1, which encodes the transcription factor hepatocyte nuclear factor (HNF)-1alpha, cause maturity-onset diabetes of the young-3. We have previously shown that a dominant-negative mutant (DN-HNF-1alpha) renders INS-1 insulinoma cells sensitive to the mitochondrial apoptosis pathway, but the underlying alterations in signal transduction remain unknown," scientists in Ireland report. H. Wobser and colleagues at the Royal College of Surgeons in Ireland...
Source: Diabetes Week (2006-04-10)
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