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Diabetes Pathogenesis
Findings describe new data in diabetes pathogenesis research
April 10th, 2006
Diabetes pathogenesis research advances have been reported from the United States. Study 1: Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. "Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the 0 cell surface by constructing a cell-type and glycoprotein-specific N-glycan ligand for pancreatic lectin receptors," investigators in the...
Source: Diabetes Week (2006-04-10)
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