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Diabetes Pathogenesis
HNF-4 alpha is essential for glucose stimulated insulin secretion by pancreatic beta-cells
April 10th, 2006
Hepatocyte nuclear factor-4 alpha is essential for glucose stimulated insulin secretion by pancreatic beta-cells. According to a study from Japan, "Mutations in the hepatocyte nuclear factor (HNF)-4 alpha gene cause a form of maturity-onset diabetes of the young (MODY1) that is characterized by impairment of glucose-stimulated insulin secretion by pancreatic beta-cells. HNF-4 alpha, a transcription factor belonging to the nuclear receptor superfamily, is expressed in pancreatic islets as well as in the liver, kidney, and intestine. However, the role of HNF-4 alpha in pancreatic beta-cell is unclear." A. Miura and colleagues at Osaka University...
Source: Diabetes Week (2006-04-10)
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