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Diabetes Pathogenesis
Tissue degeneration in hearts could be caused by increased cell-cycle arrest and DNA repair
April 10th, 2006
Increased activation of genes inducing cell-cycle arrest and DNA repair in the hearts of rats with early streptozotocin-induced diabetes mellitus could lead to tissue degeneration. According to recent research from Germany, "Oxidative stress was proposed as a critical factor in diabetic complications. The etiology of cell degeneration in diabetes mellitus (DM)-induced cardiomyopathy is unclear. The transition between apoptotic degeneration and cell proliferation under stress conditions is regulated at cell-cycle checkpoints." "This study," explained O. Golubnitschaja and colleagues, University Bonn, "was aimed at elucidating the role of a potent...
Source: Diabetes Week (2006-04-10)
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