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Diabetes Pathogenesis
MCH-/- mice are resistant to aging-associated raises in body weight and insulin resistance
April 10th, 2006
MCH ablation may improve the long-term outcome for several indicators of the aging process. "Ablation of the hypothalamic peptide, melanin-concentrating hormone (MCH), leads to a lean phenotype and resistance to diet-induced obesity. Observation of MCH-/- mice at older ages suggested that these effects persist in mice >1 year old," scientists writing in the journal Diabetes report. "Leanness secondary to caloric restriction is known to be associated with improved glucose tolerance as well as an overall increase in life span. Because the MCH-/- model represents leanness secondary to increased energy expenditure rather...
Source: Diabetes Week (2006-04-10)
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