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Diabetes Pathogenesis
New findings in the area of diabetes pathogenesis described
April 10th, 2006
Investigators in the United Kingdom, United States and Sweden have published new diabetes pathogenesis data. Study 1: Nnt mutations/deletion uncouple beta cell mitochondrial metabolism leading to impaired insulin secretion. "The C57BL/6J mouse displays glucose intolerance and reduced insulin secretion. QTL mapping identified nicotinamide nucleotide transhydrogenase (Nnt), a nuclear-encoded mitochondrial protein thought to be involved in free radical detoxification, as a candidate gene," investigators in England report. H. Freeman and colleagues working with the Medical Research Council described, "To investigate its functional...
Source: Diabetes Week (2006-04-10)
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