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Diabetes Pathogenesis
New findings in the area of diabetes pathogenesis detailed
April 10th, 2006
Data on diabetes pathogenesis are outlined in reports from Sweden, the United States and Switzerland. Study 1: Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells were evaluated. "Cyclic AMP is a ubiquitous second messenger that transduces signals from a variety of cell surface receptors to regulate diverse cellular functions, including secretion, metabolism and gene transcription. In pancreatic beta-cells, cAMP potentiates Ca2+-dependent exocytosis(1-3) and mediates the stimulation of insulin release exerted by the hormones glucagon and glucagon-like peptide-1 (GLP-1) (refs 4-6)," scientists writing in the...
Source: Diabetes Week (2006-04-10)
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