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Diabetes Pathogenesis
Phosphorylation of JNK in diabetic rat sensory neurons may impair nerve conduction
April 10th, 2006
Phosphorylation of c-Jun N-terminal kinase in sensory neurons of diabetic rats may impair nerve conduction. "This study was designed to determine whether diabetes in rats is associated with phosphorylation of c-Jun N-terminal kinase (JNK) and one of its transcription factors, c-Jun, in sensory neurons innervating the lower limb. We also sought to determine which neuronal phenotypes are affected and to examine the effect of aldose reductase inhibition on JNK and c-Jun phosphorylation. Diabetes was induced in rats using streptozotocin," scientists in England report. A.B. Middlemas and colleagues at the University of Manchester explained,...
Source: Diabetes Week (2006-04-10)
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