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Diabetes Pathogenesis
Research in diabetes pathogenesis provides new insights
April 10th, 2006
Reports from the United States and Israel highlight recent research on diabetes pathogenesis. Study 1: Overexpression of the coactivator Bridge-1 results in insulin deficiency and diabetes. "Multiple forms of heritable diabetes are associated with mutations in transcription factors that regulate insulin gene transcription and the development and maintenance of pancreatic beta-cell mass. The coactivator Bridge-1 (PSMD9) regulates the transcriptional activation of glucose-responsive enhancers in the insulin gene in a dose-dependent manner via PDZ domain-mediated interactions with E2A transcription factors," researchers in the United States...
Source: Diabetes Week (2006-04-10)
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