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Diabetes Pathogenesis
Researchers detail new studies and findings in the area of diabetes pathogenesis
April 10th, 2006
Diabetes pathogenesis data are the focus of recent research from the United Kingdom, Belgium and United States. Study 1: Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. "Long-term exposure of beta cells to lipids, particularly saturated fatty acids in vitro, results in cellular dysfunction and apoptosis (lipotoxicity); this could contribute to obesity-related diabetes. Our aims were to relate cell death to intracellular triglyceride concentration, composition and localization following incubation of INS1 cells in saturated and unsaturated NEFA in high and low glucose...
Source: Diabetes Week (2006-04-10)
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