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Diabetes Pathogenesis
Smad7 expression in beta cells disrupts TGF-beta signaling and induces reversible diabetes
April 10th, 2006
Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. According to recent research published in the journal Plos Biology, "Identification of signaling pathways that maintain and promote adult pancreatic islet functions will accelerate our understanding of organogenesis and improve strategies for treating diseases like diabetes mellitus. Previous work has implicated transforming growth factor-beta (TGF-beta) signaling as an important regulator of pancreatic islet development, but has not established whether this signaling pathway is required for essential islet functions in the adult...
Source: Diabetes Week (2006-04-10)
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