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Diabetes Week

Susan Hasty, Publisher

Table of Contents . . . April 17th, 2006

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Diabetes Week | Other Publications

Atherosclerosis - Valsartan may be beneficial as an antiatherosclerotic therapy in type 2 diabetes

Cerebrovascular Disease & Diabetes - Cerebrovascular disease linked to heart rate differences in nonhypertensive diabetics

Diabetes Pathogenesis - Cortisol correlates with metabolic disturbances in population study of type 2 diabetics

Diabetes Therapy - Eicosapentaenoic acid improves diabetic nephropathy of type 2 diabetic KKAy/Ta mice

Genetics & Genomics - Aortic endothelial gene expressions were normalized after insulin therapy in diabetic rats

Adipose Tissue - New findings in the area of adipose tissue described

Angiology - Mesenteric fat thickness is linked to metabolic syndrome and cardiovascular disease risk

Angiology - Protein tyrosine phosphatase inhibition improves vascular endothelial dysfunction

Atherosclerosis - Angiogenesis is impaired by rosiglitazone's effects on endothelial cells

Atherosclerosis - RAGE modulates vascular inflammation and atherosclerosis in a murine type 2 diabetes model

Atherosclerosis - Serum paraoxonase activity is tested using semiautomated method with paraoxon as substrate

Cardiovascular Disease - Insulin resistance predicts carotid intimal medial thickness in hypertension

Cardiovascular Research - Increased hexosamine and O-GlcNAc levels may protect against calcium paradox and ischemia

Clinical Trials - Enrollment completed in phase 1 trial of intravitreal implant in diabetic macular edema

Clinical Trials - Preliminary results reported from Generex Oral-lyn trial in young adults with type 1 diabetes

Clinical Trials - Spherix meets overseas CRO, moves to finalize phase 3 trial of Naturlose for diabetes

Critical Care Medicine - Intensive insulin therapy is linked to cost savings compared with standard insulin therapy

Diabetes & Alzheimer Disease - Type 2 diabetes mellitus may influence outcome of concurrent late-onset Alzheimer disease

Diabetes & Heart Disease - Increased oxidative stress plasma markers are linked to CHD in diabetes mellitus

Diabetes Complications - Erectile function is restored to diabetic rats given angiogenic protein

Diabetes Complications - Insulin-dependent DM incurred right ventricular remodeling and left ventricular dysfunction

Diabetes Complications - Islet cell autoimmunity is common in autoimmune endocrine patients in central Africa

Diabetes Complications - Median duration to end-stage renal disease has been prolonged in patients with type 1 diabetes

Diabetes Complications - Metabolic syndrome is associated with an increased aortic stiffness

Diabetes Control - Moderate exercise improved whole-day glycemic control in obese with type 2 diabetes

Diabetes Diagnostics - Family history of diabetes increased diabetes risk, risk awareness, and risk-reducing behavior

Diabetes Diagnostics - New dynamic index of insulin sensitivity proposed

Diabetes Epidemiology - Autoimmune diseases within individuals and families can increase other autoimmune risk

Diabetes Epidemiology - Insulin-dependent loci Idd5 and Idd9 increase autoimmune encephalomyelitis sensitivity

Diabetes Epidemiology - NF kappa B1 gene does not affect type 1 diabetes predisposition in Spanish population

Diabetes Epidemiology - Researchers' findings advance diabetes epidemiology research

Diabetes Pathogenesis - Adiponectin could influence insulin resistance development in lean offspring of type 2 diabetics

Diabetes Pathogenesis - Aminoguanidine prevented blood antioxidant system impairment in diabetic rats

Diabetes Pathogenesis - Cannabinoid CB1 receptor activation induces glucose intolerance in rats

Diabetes Pathogenesis - Ceramides contribute to the development of insulin resistance

Diabetes Pathogenesis - Diabetic glomerulopathy morphological parameters deteriorate in normoalbuminuric diabetics

Diabetes Pathogenesis - Findings in diabetes pathogenesis provide new insights

Diabetes Pathogenesis - High platelet FcR expression and low LDL cholesterol levels more common in type 2 diabetes

Diabetes Pathogenesis - New data illuminates research in diabetes pathogenesis

Diabetes Pathogenesis - Nitric oxide metabolism cannot predict type 1 diabetes development in children

Diabetes Pathogenesis - Recent findings in diabetes pathogenesis described

Diabetes Pathogenesis - Recent studies add new data to diabetes pathogenesis research

Diabetes Pathogenesis - Reports add new data to diabetes pathogenesis research

Diabetes Pathogenesis - Researchers describe findings in diabetes pathogenesis studies

Diabetes Pathogenesis - Too much or too little sleep increases diabetes risk for men

Diabetes Pathogenesis - Vasopressin is not crucial for HPA axis regulation during diabetes-induced chronic stress

Diabetes Pathogenesis - mGLUT 9 splice variants are expressed in liver and kidney and are upregulated in diabetes

Diabetes Research - Gene technology increases pancreatic islet cell survivability in animal study

Diabetes Research - In type 2 diabetes, heart rate variability and urinary albumin excretion link is strong only with macroalbuminuria

Diabetes Research - Researchers reverse diabetes in mouse model; clinical trial to begin

Diabetes Therapy - ACE inhibitor benefits in diabetes are due to protective action on pancreatic beta-cells

Diabetes Therapy - AMP-activated protein kinase is proposed as pharmacological target for type 2 diabetes therapy

Diabetes Therapy - Cyclohexenonic long-chain fatty alcohol improves hyperreactivity of diabetic aorta

Diabetes Therapy - Findings advance knowledge in diabetes therapy research

Diabetes Therapy - Glimepiride-cyclodextrin-polymer system improved glimepiride efficacy in diabetes therapy

Diabetes Therapy - Low-dose ramipril plus candesartan was a safe treatment in diabetics with kidney disease

Diabetes Therapy - Oleuropein may be valuable in inhibiting diabetes-induced hyperglycemia and oxidative stress

Diabetes Therapy - Reports advance knowledge in diabetes therapy research

Diabetes Therapy - Researchers' work adds to diabetes therapy body of knowledge

Diabetes Therapy - Studies advance knowledge in diabetes therapy research

Diabetes Therapy - Studies describe new findings in diabetes therapy research

Diabetes Therapy - Taurine supplementation shows potential in diabetes mellitus treatment

Diabetes Therapy - Topical ketanserin is effective therapy for leg ulcers in patients with diabetes

Diagnostics - Preadipocyte differentiation assay was developed for screening antidiabetes drugs

Diet & Nutrition - Antiobesity and antidiabetic effects of tea catechins reviewed

Diet & Nutrition - Chronic high-fat and high-sucrose diets differentially affect glucose intolerance in mice

Diet & Nutrition - Coffee consumption and its link to improved glucose tolerance are reviewed

Diet & Nutrition - Conjugated LA isomers reduce blood cholesterol in hypercholesterolemic hamsters

Diet & Nutrition - Dietary CLnA exerts antioxidant activity in chemically induced diabetes mellitus

Diet & Nutrition - S-adenosylmethionine with vitamins C and E protect against insulin resistance

Diet & Nutrition - alpha-Cyclodextrin reduces glycemic response to carbohydrate meal in dose-dependent manner

Drug Delivery - Insulin delivery carrier SS-ILP could control blood glucose levels in diabetic rats

Drug Development - VistaGen, Cato BioVentures sign strategic business development agreement for CNS products

Endocrinology - Digitonin enhanced glucose tolerance and improved antioxidant activity and serum lipids

Finance - Ceapro successfully closes $1.3 million financing

Finance - ConjuChem announces $9.7 million first quarter net loss

Finance - Metabasis Therapeutics reports boosted fourth quarter revenues from Merck alliance

Finance - Salick Cardiovascular Centers obtains a $75 million series A financing from Warburg Pincus

Finance - Two European funds agree to Dermisonics' financing

Finance - William Blair initiates coverage of Amylin Pharmaceuticals, Inc. with market perform rating

Genetics & Genomics - Adiponectin gene is linked to adiponectin levels but not insulin resistance syndrome

Genetics & Genomics - SREBF-1 gene variant is significantly related to cholesterol synthesis

Genetics & Genomics - Transcription factor 7-like 2 (TCF7L2) gene variant confers type 2 diabetes risk

HIV/AIDS Prognostics - Low adiponectin levels predict VLDL and IDL apolipoprotein B fractional clearance rates

Healthcare Coverage - Healthways, BCBS of Massachusetts extend, expand agreement under new, 5-year partnership

Hypertension - Researchers detail new studies and findings in the area of hypertension

Ischemia - Diabetic nerve shows delayed recovery of ischemic conduction failure after brief ischemia

Market Analysis - IMS Health reports global pharmaceutical market grew 7% in 2005, to $602 billion

Medical Devices - OrSense's noninvasive glucose sensor achieves accurate performance in acute care setting

Mergers & Acquisitions - Keryx enters agreement to acquire marketed diagnostic for detection of microalbuminuria

Metabolic Syndrome - Studies add new findings to metabolic syndrome body of knowledge

Metabolic Syndrome Risk Factors - Small dense ow-density lipoprotein might be a risk factor for metabolic syndrome development

Natural Products -  Aloe vera leaf gel extract appears to improve the lipid profile of diabetic rats

Natural Products - Antiobesity effect of epigallocatechin gallate from green tea deserves more attention

Neuropathic Pain - Sangamo Biosciences announces positive Phase 1 results in patients with diabetic neuropathy

Obesity Complications - Weight loss induced cortisol metabolism changes not affected by metabolic syndrome symptoms

Obesity Pathogenesis - Adipocyte fatty acid-binding protein is obesity and metabolic syndrome-related biomarker

Obesity Pathogenesis - Hepatic leptin resistance due to PTP1B overexpression may lead to diabetes and obesity

Obesity Pathogenesis - Researchers report details of new studies and findings in the area of obesity pathogenesis

Obesity Pathogenesis - Systemic MCP-1 concentrations are independent of type 2 diabetes or obesity parameters

Peripheral Vascular Disease - Therapeutic angiogenesis falls short in ischemic limbs deprived of CD34-positive cells

Personnel - Insulet Corp. names Ruthann DePietro vice president of quality and regulatory affairs

Personnel - MicroIslet appoints Bertram Walls, MD, to board of directors

Pharmaceutical Research - Rosuvastatin enhanced apoB degradation in insulin resistant and metabolic dyslipidemia model

Polycystic Ovary Syndrome - Polycystic ovary syndrome may be associated with reduced leptin receptor levels

Proteomics - Proteome and transcriptome markers of autoimmune diabetes risk identified

Quality Assurance - PSivida announces drug delivery device certified to be GMP equivalent to E.U. standards

Restenosis - TAXUS stents superior to brachytherapy in the treatment of in-stent restenosis, study reports

Sleep Apnea - Metformin improves sleep apnea, showing that insulin resistance may impair ventilation control

Stroke - Stroke risk is increased in men with metabolic syndrome

Transplant Medicine - Positive results reported in animal diabetes experiments of pancreatic xenotransplantation

Type 1 Diabetes - Cerebral glutamate metabolism during hypoglycemia in TID may play role in autonomic failure

Type 2 Diabetes - Clinical nephropathy is a predictor of early and late mortality in type 2 diabetes

Type 2 Diabetes - Diabetes risk may be lowered by dietary exchange to high-fiber bread

Type 2 Diabetes - In polycystic ovary syndrome patients, method to identify diabetes risk has been identified

Type 2 Diabetes - PhytoMedical enters into expanded collaborative agreement for type 2 diabetes compound

Type 2 Diabetes - Type 2 diabetes does not appear to be associated with dietary lycopene/tomato-based foods

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