Diabetes Pathogenesis
Chaperonin 60 may indicate mitochondrial dysfunction in diabetic central nervous system
Published in Diabetes Week, April 24th, 2006
According to a study from New Zealand, "Mitochondrial dysfunction and oxidative stress are implicated in the pathological changes observed in the diabetic central nervous system. In this study, using the streptozotocin-induced diabetic rat model we document for the first time the overexpression of a mitochondrial specific stress protein (chaperonin 60) in the CAI/CA3 regions of the diabetic hippocampus in the absence of neurodegeneration."
"The increase in expression of chaperonin 60 was not observed in the cohort treated with insulin,...
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Source: Diabetes Week (2006-04-24)
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