Diabetes Pathogenesis
Increased pp38MAPK and pHSP25 comprise acute adaptation to glycemic stress in diabetes
Published in Diabetes Week, April 24th, 2006
"Phosphorylated p38 (pp38) mitogen-activated protein kinase (MAPK) regulates heat shock protein 25 (HSP25), stabilizing fibrillar actin (FA) and preventing cleavage to G-actin (GA). Cultured podocytes (Pods) were exposed to glucose (5.5-50 mM)±p38MAPK inhibitor SB202190 (SB) or control SB202474 to assess the effects on FA/GA and Pod structure," scientists writing in the journal Kidney International report.
T. Dai and colleagues working with the Harbor UCLA Los Angeles Biomedical Research Institute explained, "The relationship of p38MAPK with in...
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Source: Diabetes Week (2006-04-24)
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