Diabetes Therapy
Glucose-dependent insulinotropic peptides are long-acting stable analogues for diabetes therapy
Published in Diabetes Week, April 24th, 2006
According to a study from North Ireland, "Glucose-dependent insulinotropic polypeptide (GIP) is a physiological insulin releasing peptide. We have developed two novel fatty acid derivatized GIP analogues, which bind to serum albumin and demonstrate enhanced duration of action in vivo."
"GIP(Lys16PAL) and GIP(Lys37PAL) were resistant to dipeptidyl peptidase IV (DPP IV) degradation. In vitro studies demonstrated that GIP analogues retained their ability to activate the GIP receptor through production of...
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Source: Diabetes Week (2006-04-24)
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