Diabetic Nephropathy
Angiotensin II-dependent Src and Smad1 signaling pathway is key to diabetic nephropathy
Published in Diabetes Week, October 23rd, 2006
According to recent research from Japan, "Angiotensin II (Ang II) is known to play a pivotal role in the development of diabetic nephropathy. However, the precise mechanism of Ang II-mediated effects on diabetic nephropathy is still unknown. We have reported that Smad1 plays a key role in diabetic mesangial matrix expansion and directly regulates the transcription of type IV collagen (Col4) in vitro and in vivo."
"Here," wrote A. Mima and colleagues at Kyoto University, "we examined the effect of Ang II on the expression of Smad1 and...
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Source: Diabetes Week (2006-10-23)
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