Proteomics
Reports summarize proteomics research from Institute of Cell and Molecular Science
Published in Diabetes Week, January 1st, 2007
Current study results from the report, "Altered monocyte cyclooxygenase response to lipopolysaccharide in type 1 diabetes," have been published. According to recent research from London, the United Kingdom, "Type 1 diabetes is caused by adaptive immune responses, but innate immunity is important because monocytes infiltrate islets. Activated monocytes express cyclooxygenase (COX)-2, promoting prostaglandin-E(2) (PGE(2)) secretion, whereas COX-1 expression is constitutive."
"We aimed to define monocyte COX expression in type 1 diabetes basally and after lipopolysaccharide (LPS) stimulation. Isolated CD14(+) monocytes were analyzed for COX mRNA and protein expression from...
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Source: Diabetes Week (2007-01-01)
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