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Drug Development

Insulin sensitizer MBX-102/JNJ-39659100 reduces inflammation in preclinical diabetes models

Published in Diabetes Week, February 12th, 2007

Metabolex, Inc., a biotechnology company focused on the discovery and development of novel therapeutics for diabetes and related metabolic disorders, announced the results from a preclinical program that showed that MBX-102/JNJ-39659100, an insulin sensitizer, reduces inflammation in mouse and rat models of diabetes.

Metabolex investigators, presenting at the Keystone Symposium in Keystone, Colorado, compared the effect of MBX-102/JNJ-39659100, rosiglitazone and a vehicle treatment. MBX-102/JNJ-39659100 was previously referred to as metaglidasen.

Both mice and rats treated with either active compound demonstrated substantially reduced inflammation...

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