Gene Therapy

New gene therapy study findings have been reported by researchers at Genzyme Corporation, Department of Molecular Biology

Published in Diabetes Week, February 12th, 2007

A new study, "Ectopic expression of glucagon-like peptide 1 for gene therapy of type II diabetes," is now available. "Glucagon-like peptide 1 (GLP-1) is a promising candidate for the treatment of type II diabetes. However, the short in vivo half-life of GLP-1 has made peptide-based treatments challenging," scientists writing in the journal Gene Therapy report.

"Gene therapy aimed at achieving continuous GLP-1 expression presents one way to circumvent the rapid turnover of GLP-1. We have created a GLP-1 minigene that can direct the secretion of active GLP-1 (amino acids 7-37). Plasmid and adenoviral expression vectors encoding the 31-amino-acid peptide linked to...

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Source: Diabetes Week (2007-02-12)

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