Life Sciences

Findings from University of Texas provide new insights into life sciences

Published in Diabetes Week, May 19th, 2008

According to a study from the United States, "The kidney contains two Na+/glucose cotransporters, called SGLT2 and SGLT1, arranged in series along the length of the proximal tubule. The low-affinity transporter, SGLT2, is responsible for the reabsorption of most of the glucose in the kidney."

"There is recent interest in SGLT2 as a target for the treatment of type II diabetes using selective inhibitors based on the structure of the phenylglucoside, phlorizin (phloretin-2 '-beta-glucoside). In this study, we examined the inhibition of alpha-methyl-D-glucopyranose transport by phlorizin and a new candidate drug, sergliflozin-A [(2-[4-methoxyphenyl]methyl)phenyl...

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Source: Diabetes Week (2008-05-19)

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