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Research
How to get obese mice moving -- and cure their diabetes
June 15th, 2009
Mice lacking the fat hormone leptin or the ability to respond to it become morbidly obese and severely diabetic—not to mention downright sluggish. Now, a new study in the June Cell Metabolism shows that blood sugar control in those animals can be completely restored by returning leptin sensitivity to a single class of neurons in the brain, which account for only a small fraction of those that normally carry the hormone receptors. "Just the receptors in this little group of neurons are sufficient to do the job," said Christian Bjorbaek of Harvard Medical School. What's more, animals with leptin receptors only in the so-called pro-opiomelanocortin (POMC) neurons...
Source: Diabetes Week (2009-06-15)
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