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Diabetes
Findings from A. Benardeau and co-authors broaden understanding of diabetes
June 15th, 2009
"synthesis, and SAR of novel alpha-alkoxy-beta-arylpropionic acids as potent and balanced PPAR alpha gamma coagonists are described," scientists writing in the journal Bioorganic & Medicinal Chemistry Letters report. "One representative thereof, Aleglitazar ((S)-2Aa), was chosen for clinical development," wrote A. Benardeau and colleagues. The researchers concluded: "Its X-ray structure in complex with both receptors as well as its high efficacy in animal models of T2D and dyslipidemia are also presented." Benardeau and colleagues published their study in Bioorganic & Medicinal Chemistry Letters (Aleglitazar, a new,...
Source: Diabetes Week (2009-06-15)
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