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Atherosclerosis
Findings from Cornell University advance knowledge in atherosclerosis
July 13th, 2009
"Thiazolidinediones, a class of drugs for the treatment of type-2 diabetes, are synthetic ligands for peroxisome proliferator-activated receptor-gamma. They have been demonstrated to possess cardioprotective effects in humans and anti-atherogenic properties in animal models," scientists writing in the American Journal of Pathology report. "However, the question remains whether a peroxisome proliferator-activated receptor-gamma ligand can reverse the development of atherosclerosis. In this study, we tested the effects of pioglitazone on the development of established atherosclerosis in low-density lipoprotein receptor-null mice. We observed that atherosclerosis in...
Source: Diabetes Week (2009-07-13)
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