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Yale University
Yale discovery may open door to drug that cuts appetite and boosts energy
August 3rd, 2009
In a major advance in obesity and diabetes research, Yale School of Medicine scientists have found that reducing levels of a key enzyme in the brain decreased appetites and increased energy levels. Reductions in the levels of the enzyme prolylcarboxypeptidase (PRCP) led to weight loss and a decreased risk of type 2 diabetes in mice, according to research published in the August issue of the Journal of Clinical Investigation. The team found that PRCP is located in the hypothalamus and regulates levels of the alpha-melanocyte stimulating hormone (alpha-MSH), which is a peptide known for inhibiting food intake and stimulating energy expenditure. Researchers found that...
Source: Diabetes Week (2009-08-03)
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