Banaras Hindu University, Urtar Pradesh
Sex steroids reduce DNasel accessibility of androgen receptor promoter in brain
Published in Disease Prevention Week, March 1st, 2005
"We have previously reported that androgen receptor (AR) expression is inversely correlated to its promoter methylation and is regulated by sex steroids.
"As chromatin structure plays an important role in transcriptional regulation, the effect of sex steroids on DNasel accessibility of chromatin of AR promoter was examined in the brain cortex of adult and old mice of both sexes," investigators in India report.
"Nuclei were digested with different concentrations of DNasel and the extracted DNA was further cleaved by PstI and analyzed by...
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