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Benaroya Research Institute of Virginia Mason
T-cells with high antigen avidity are prevalent in diabetic patients
October 17th, 2004
GAD65-Specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. "Negative selection of self-reactive T-cells during thymic development, along with activation-induced cell death in peripheral lymphocytes, is designed to limit the expansion and persistence of autoreactive T-cells. Autoreactive T-cells are nevertheless present, both in patients with type 1 diabetes and in at-risk subjects. By using MHC class II tetramers to probe the T-cell receptor (TcR) specificity and avidity of GAD65 reactive T-cell clones isolated from patients with type 1 diabetes, we identified high-avidity CD4+ T-cells in peripheral blood,...
Source: Disease Risk Factor Week (2004-10-17)
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