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Albert Einstein College of Medicine
Cryptococcus glucuronoxylomannan IgM have diverse gene use profiles
October 17th, 2004
Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles. "The features of protective murine antibodies to the Cryptococcus neoformans capsular polysaccharide glucuronoxylomannan (GXM) have been rigorously investigated; however, the characteristics of protective human antibodies to GXM have not been defined. We produced monoclonal antibodies (MAbs) from XenoMouse mice (transgenic mice that express human immunoglobulin M [IgM], IgG2, and K), which were immunized with a C. neoformans serotype D strain 24067 GXM-diphtheria toxoid...
Source: Disease Risk Factor Week (2004-10-17)
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