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Abbott Laboratories
Serum-free IC50 values determined for lopinavir and ritonavir
October 17th, 2004
Serum-free IC50 values were determined for lopinavir and ritonavir. "Using measured free fraction and 50% inhibitory concentration (IC50 ) values for the human immunodeficiency virus protease inhibitors lopinavir (LPV) and ritonavir (RW) in tissue culture media with various protein concentrations ranging from 5 to 50%, we estimated serum-free IC50 values for each drug," scientists writing in the journal Antimicrobial Agents and Chemotherapy report. "The range of serum-free IC50 values (0.64 to 0.77 ng/ml for LPV and 3.0 to 5.0 ng/ml for RW) did not exhibit a trend with increasing protein concentrations," said...
Source: Disease Risk Factor Week (2004-10-17)
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