Antigen Express Inc.
Hybrid peptide enhances CD4+ T-cell response in DR4-transgenic mice
Published in Disease Risk Factor Week, August 28th, 2005
"Linking the Ii-Key functional group LRMK, through a simple polymethylene linker, to the melanoma gp 100(48-58) MHC class 11 epitope significantly enhances the vaccine response to that epitope in DR4-IE transgenic mice. A homologous series of IiKey/gp100(46-58) hybrids was synthesized to test the influence of spacer length (between Ii-Key and the gp100(48-58) epitope) on in vivo enhancement of gp100(48-58)-specific CD4+ T-lymphocyte responses," scientists writing in the Journal of...
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