Akdeniz University, Antalya
Adenovirus-mediated expression sensitizes prostate carcinoma cells to apoptosis
Published in Disease Risk Factor Week, February 19th, 2006
"Despite the fact that TRAIL can selectively induce apoptosis in cancer cells, TRAIL resistance in cancer cells has challenged the use of TRAIL as a therapeutic agent. First, prostate carcinoma cell lines (DU145, LNCaP and PC3) were screened for sensitivity to adenovirus delivery of TRAIL (Ad5hTRAIL)," wrote A.D. Sanlioglu and colleagues, Akdeniz University.
"As amplified Ikappa B kinase (IKK) activity is responsible for the constitutive nuclear...
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