Alzheimer Disease

Reports outline alzheimer disease study results from University of Saskatchewan, Department of Psychiatry

Published in Disease Risk Factor Week, January 14th, 2007

A report, "Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis," is newly published data in Journal of Neurochemistry. "Aldehydes are capable of inducing protein cross-linkage. An increase in aldehydes has been found in Alzheimer's disease," investigators in Saskatoon, Canada report.

"Formaldehyde and methylglyoxal are produced via deamination of, respectively, methylamine and aminoacetone catalyzed by semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6. The enzyme is located on the outer surface of the vasculature, where amyloidosis is often initiated. A high SSAO level has been identified as a risk factor...

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Source: Disease Risk Factor Week (2007-01-14)

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