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Acute Myeloid Leukemia Therapy

Findings from German Cancer Research Center advance knowledge in acute myeloid leukemia therapy

Published in Disease Risk Factor Week, June 1st, 2008

Research findings, 'Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups,' are discussed in a new report. According to recent research from Heidelberg, Germany, "Drug metabolism/disposition and transporter genes may influence predisposition or prognosis of AML (acute myeloid leukemia) patients. We analyzed polymorphisms in 3 transporters and 4 drug metabolism genes in 293 Israeli individuals (112 AML patients and 181 controls)."

"We analyzed: ABCC3 (MRP3) C-211T; ABCG2 (BCRP) C421A; CNT1 (SLC28A1) G565A and NAT1, NAT2, and GSTT1 and...

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