Boston University
Telomere homolog oligonucleotides induce senescence in malignant fibroblasts
Published in Drug Law Weekly, February 8th, 2005
According to recent research from the United States, "cellular senescence is a major defense against cancer. In human fibroblasts, suppressing both the p53 and pRb pathways is necessary to bypass replicative senescence as well as senescence induced by ectopic expression of a dominant negative form of the telomere repeat binding factor 2, TRF2(DN)."
"We recently reported that exposure to oligonucleotides homologous to the telomere 3' overhang (T-oligos) activates both the p53 and pRb pathways and leads to senescence in primary human fibroblasts," said G.Z. Li and colleagues,...
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Source: Drug Law Weekly (2005-02-08)
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