Columbia University, New York

Research reveals structure of antidepressants' binding sites

Published in Drug Law Weekly, August 16th, 2005

Some of the body's most important signaling molecules - such as serotonin and dopamine - rely on transporters to successfully clear them out of the extracellular space in the brain. Transporters move these neurotransmitters across the cell membrane by capitalizing on differences in ionic gradients.

Eric Gouaux and his colleagues at Columbia University have now captured the crystal structure of a bacterial sodium/chloride-dependent transporter, which moves leucine across membranes.

The structure, detailed in a paper published online July 24, 2005, by Nature, is the first glimpse of this large class of neurotransmitter sodium symporters.

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Source: Drug Law Weekly (2005-08-16)

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