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CHU Nancy

Pathophysiology of anaphylaxis during anesthesia characterized

Published in Drug Law Weekly, August 16th, 2005

The physiological features of anaphylactic shock have been elucidated in surgical patients under anesthesia.

"The pathophysiology of anaphylactic shock during anesthesia is incompletely characterized," anesthesiologists in France noted. "It is described as distributive by analogy with septic shock (anaerobic metabolism, high tissue oxygen pressure (PtiO2 ) values)," but the "PtiO2 profile and its metabolic consequences during anaphylaxis are not known."

In a study conducted by P. Dewachter and coauthors at CHU Nancy, "ovalbumin-sensitized anaphylactic shock rats (n=11) were compared to nicardipine-induced hypotension rats...

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