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Astellas Pharma, Japan
Scientists at Astellas Pharma, Inc. publish research in biopharmaceutics
November 7th, 2006
Scientists discuss in "In vitro drug interaction between diflunisal and indomethacin via glucuronidation in humans" new findings in biopharmaceutics. "It was reported that the plasma concentration of indomethacin was increased with concomitant oral dosages of diflunisal in humans. Both indomethacin and diflunisal are glucuronidated in humans," scientists in Tokyo, Japan report. "The effects of diflunisal on the indomethacin glucuronidation were thus investigated in vitro using human liver microsomes (HLM) and human intestine microsomes (HIM) in order to assess the drug-drug interaction. The glucuronidation of indomethacin in HLM showed atypical kinetics with Km and Ksi...
Source: Drug Law Weekly (2006-11-07)
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