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Allegheny General Hospital, Pittsburgh, U.S.
Pseudomonas aeruginosa genomic plasticity revealed among clinical isolates
November 7th, 2006
A study from the United States has reported that extensive genomic plasticity in Pseudomonas aeruginosa is revealed by identification and distribution studies of novel genes among clinical isolates. "The distributed genome hypothesis (DGH) states that each strain within a bacterial species receives a unique distribution of genes from a population-based supragenome that is many times larger than the genome of any given strain. "The observations that natural infecting populations are often polyclonal and that most chronic bacterial pathogens have highly developed mechanisms for horizontal gene transfer suggested the DGH and provided the means...
Source: Drug Law Weekly (2006-11-07)
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