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Boston University, U.S.
Data on DNA research detailed by researchers at Boston University, Department of Dermatology
November 7th, 2006
Current study results from the report, "A role for WRN in telomere-based DNA damage responses," have been published. According to recent research from the United States, "Telomeres cap the ends of eukaryotic chromosomes and prevent them from being recognized as DNA breaks. We have shown that certain DNA damage responses induced during senescence and, at times of telomere uncapping, also can be induced by treatment of cells with small DNA oligonucleotides homologous to the telomere 3' single-strand overhang (T-oligos), implicating this overhang in generation of these telomere-based damage responses." "Here, we show that T-oligo-treated fibroblasts contain gammaH2AX foci...
Source: Drug Law Weekly (2006-11-07)
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