Cardiology

Neointimal growth after vascular injury requires protein kinase C

Published in Drug Law Weekly, November 14th, 2006

A study from the United States has documented the essential role of protein kinase C (PKC)-zeta in normal and angiotensin II (ANG II)-accelerated neointimal growth after vascular injury.

"The contribution of atypical PKC-zeta to ANG II-accelerated restenosis after endoluminal vascular injury was investigated by using the rat carotid balloon injury model," wrote J.H. Parmentier and colleagues, University of Tennessee.

"Exposure of injured arteries to ANG II resulted in an extensive neointimal thickening (1.9 times) compared with vehicle at day 14. Treatment with PKC-zeta antisense, but not scrambled, oligonucleotides reduced neointimal formation...

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Source: Drug Law Weekly (2006-11-14)

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