Ischemia
Paradoxical coronary microcirculatory constriction during ischemia described
Published in Drug Law Weekly, November 14th, 2006
According to recent research from Italy, "A paradoxical microcirculatory constriction has been observed in hearts of patients with ischemia, secondary to coronary stenosis. Here, using the isolated mouse heart (Langendorff), we examined the mechanism of this response, assuming involvement of nitric oxide (NO) and endothelin-1 (ET-1) systems."
C. Kusmic and colleagues at CNR, Pisa wrote, "Perfusion pressure was maintained at 65 mmHg for 70 min (protocol 1), or it was reduced to 30 mmHg over two intervals, between the 20- and 40-min marks (protocol 2) or from the 20-min...
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Source: Drug Law Weekly (2006-11-14)
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