Pharmacology
Researchers from University of Iowa, Division of Pharmaceutics report recent findings in pharmacology
Published in Drug Law Weekly, November 14th, 2006
A new study, "Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450," is now available. According to a study from the United States, "Cutaneous drug reactions (CDRs) are among the most common adverse drug reactions and are responsible for numerous minor to life-threatening complications. Several arylamine drugs, such as sulfamethoxazole (SMX) and dapsone (DDS), undergo bioactivation, resulting in adduction to cellular proteins."
"These adducted proteins may initiate the immune response that ultimately results in a CDR. Recent studies have demonstrated that normal human epidermal...
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Source: Drug Law Weekly (2006-11-14)
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