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Urinary Tract Infections Therapy

Studies from University Nacional of Rosario update current data on urinary tract infections therapy

Published in Drug Law Weekly, December 26th, 2006

Data detailed in "Aryloxoalcanoic compounds induce resistance to antibiotic therapy in urinary tract infection caused by Escherichia coli" have been presented. "Clofibric acid (CL) is a compound used to control hypertriglyceridemia, and ethacrynic acid (ET) is administered to enhance diuresis. These compounds are structurally analogous to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), as they have a chlorinated phenoxy moiety," scientists in Suipacha, Argentina report.

"As these agents are mainly excreted by the renal route, they could potentially coexist with Escherichia coli in the urinary tract of infected patients. Induction of the in vitro resistance...

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