Biopharmaceutics
New biopharmaceutics research from National Institute of Pharmaceutical Education and Research discussed
Published in Drug Law Weekly, February 6th, 2007
Research findings, "Investigation on physicochemical and biological differences of cefpodoxime proxetil enantiomers," are discussed in a new report. According to recent research from India, "Cefpodoxime proxetil (CP) is a prodrug of cefpodoxime acid (CA), and is supplied as racemic mixture of R-and S-enantiomers. CP has only 50% absolute bioavailability, and the reasons responsible for low bioavailability remain poorly understood."
"The present work ascertains physicochemical and biological properties of individual isomers of CP and explores their capacity to optimize delivery of CP. Both isomers showed similar pH stability behavior, but R-isomer was more susceptible to...
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Source: Drug Law Weekly (2007-02-06)
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