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Experimental Biology

Research from Anhui Medical University, Department of Medicine provide new insights into experimental biology

Published in Drug Law Weekly, March 20th, 2007

Fresh data on experimental biology are presented in the report "Suppressive effects of leflunomide on leptin-induced collagen I production involved in hepatic stellate cell proliferation." According to recent research from Hefei, People's Republic of China, "In this manuscript, we showed that following a fibrogenic stimulus of leptin, hepatic stellate cells (HSCs) underwent a complex activation process characterized by increased proliferation and excessive deposition of type I collagen. Studies with special chemical inhibitors demonstrated that this process involved Janus protein tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT), mitogen-activated protein...

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