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Alcoholism Therapy
Studies from University of North Carolina in the area of alcoholism therapy described
April 10th, 2007
Fresh data on alcoholism are presented in the report "UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics." According to recent research from the United States, "Etoposide, an important anticancer agent, undergoes glucuronidation both in vitro and in vivo. In this study, three isomeric glucuronides of etoposide, including one phenolic (EPG) and two alcoholic glucuronides (EAG1 and EAG2), were biosynthesized in vitro with human liver microsomes (HLMs), and identified by liquid...
Source: Drug Law Weekly (2007-04-10)
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