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Angiogenesis
Investigators at University of Patras, Department of Pharmacy publish new data on angiogenesis
April 10th, 2007
Fresh data on angiogenesis are presented in the report "The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway." According to a study from Patras, Greece, "CGMP-degrading pathways have received little attention in the context of angiogenesis. In the present study we set out to determine whether cGMP-specific phosphodiesterase 5 (PDE5) inhibition affects new blood vessel growth." "Incubation of chicken chorioallantoic membranes (CAMs) in vivo with sildenafil increased vascular length in a dose-dependent manner. Moreover, incubation of cultured endothelial cells (ECs) with the PDE5 inhibitor promoted proliferation,...
Source: Drug Law Weekly (2007-04-10)
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