Lung Cancer Therapy

Research on lung cancer therapy reported by scientists at Harvard University

Published in Drug Law Weekly, April 17th, 2007

Research findings, "Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity," are discussed in a new report. According to a study from the United States, "Mutations in the EGFR kinase are a cause of non-small-cell lung cancer. To understand their mechanism of activation and effects on drug binding, we studied the kinetics of the L858R and G719S mutants and determined their crystal structures with inhibitors including gefitinib, AEE788, and a staurosporine."

"We find that the mutations activate the kinase by disrupting autoinhibitory interactions, and that they accelerate...

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Source: Drug Law Weekly (2007-04-17)

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