Prodrugs
Studies from University of Birmingham in the area of prodrugs described
Published in Drug Law Weekly, June 5th, 2007
Fresh data on prodrugs are presented in the report "Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954." According to recent research from Birmingham, the United Kingdom, "Escherichia coli nitroreductase (NTR) is a flavoprotein that reduces a variety of quinone and nitroaromatic substrates. Among these substrates is the prodrug 5-[aziridin-1-yl]-2,4-dinitrobenzamide (CB1954) that is activated by NTR to form two products, one of which is highly cytotoxic."
"NTR in combination with CB1954 has entered clinical trials for virus-directed enzyme-prodrug therapy of cancer....
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Source: Drug Law Weekly (2007-06-05)
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